Each 1 ml contains:
Magnesium sulfate 7 H2O                       100 mg

Properties and Mode of Action
MAGNESIUM SULFATE reduces striated muscle contractions by a depressant effect on the central nervous system and by reducing the release of acetylcholine at the myoneuronal junction.
MAGNESIUM SULFATE diminishes the sensitivity of the motor end plate to acetylcholine and depresses the excitability of the motor membrane.

Convulsions associated with pre-eclampsia and eclampsia of pregnancy and to control convulsions associated with acute nephritis in children. Hypomagnesaemia especially acute cases accompanied by signs of tetany.
MAGNESIUM SULFATE is indicated in uterine tetany and premature labour as a myometrial relaxant.

Dosage and Administration
Usual Adult and Adolescent Dose:
Seizures in Toxaemia of Pregnancy:

I.V. loading dose of 4 g is administered over up to 20 minutes,followed by either I.V. infusion of 1 g/hour or deeply I.M. of 5 g into each buttock then 5 g I.M. on alternate buttocks every 4 hours as needed.
Premature Labour:
Initially: 4 - 6 g by I.V. infusion (in 250 ml of Dextrose 5% or 0.9% Sodium chloride) over 20 - 30 minutes.
Maintenance Dose: I.V. infusion of 1 - 3 g/hour until contractions abate.
Mild deficiency:
1 g administered every 6 hours.
Severe deficiency:

250 mg/kg body weight within a four hour period or by:
I.V. Infusion
5 gm in 1 liter of 5% Dextrose or 0.9% solutions administered slowly over a three-hour period.
The Maximum Adult dose is 40 g/day.

Paediatric Dose:
10 - 40 mg/kg as needed to control convulsions.

MAGNESIUM SULFATE is parenterally administered in the treatment of toxaemias of pregnancy. It may produce hypotonia, hypotension and respiratory depression of the neonate, therefore it is usually not administered to the mother during the 2 hours preceding delivery unless it is the only therapy available.
Problems in humans have not been documented.

Drug Interactions
Concurrent use with calcium salts may neutralize effects of MAGNESIUM SULFATE.
Parenteral MAGNESIUM SULFATE in digitalized patients may cause cardiac conduction defects.
MAGNESIUM SULFATE potentiates the action of neuromuscular blockade.
MAGNESIUM SULFATE may potentiate the action of C.N.S. depressants.

Heart block, renal failure (Creatinine clearances < 20 ml/min.) and intolerance to MAGNESIUM SULFATE.

Side effects
Parenteral MAGNESIUM SULFATE injection may cause flushing, hypotension, hypothermia, hypotonia, reduced heart rate and reduced respiratory rate.

Box of 5 or 50 ampoules of 10 ml each.