Composition
Each tablet contains:
Cetrizine                       10 mg

Properties and Mode of Action
EPIRIZINE is an antihistaminic H-1 receptor antagonist with some mast cell stabilizing activity.It is a long-acting antihistaminic with low central sedative activity.
EPIRIZINE has also antiemetic properties.
EPIRIZINE is rapidly absorbed from the gastrointestinal tract after oral administration, peak plasma concentrations being attained in about 1 hour. It is highly bound to plasma proteins and has a plasma half-life of about 11 hours. It is excreted primarily in the urine mainly as unchanged drug and does not appear to cross the blood-barrier to a significant extent. Traces of the drug have been detected in breast milk.

Indications
For the symptomatic relief of hypersensitivity reactions including rhinitis, allergic conjunctivitis, acute and chronic urticaria and other allergic dermatologic disorders.

Dosage and Administration
Adults and Children 12 years and Older:
One tablet once daily.

Precautions
In patients with renal impairment, it is recommended that the dosage be reduced to half the usual daily dose.
If the patient taking EPIRIZINE feels sedation, he must be advised not to drive vehicles or to operate machinery.
Safety during pregnancy has not been established yet, therefore EPIRIZINE should be used only if potential benefit justifies potential risk.
As the active ingredient of EPIRIZINE is excreted in breast milk, it is not indicated in lactating women.

Side effects
EPIRIZINE is generally well-tolerated, little antimuscarinic side effects, mild sedation and occasional gastrointestinal side effects as nausea and vomiting may occur.

Presentation
Box of 1 strip of 10 tablets.