Each tablet contains:
Clonazepam   2 mg
Properties and Mode of Action
CLOPAM is a benzodiazepine derivative with marked antiepileptic properties.
It potentiates the inhibitory action of gamma-amino butyric acid in the C.N.S.
CLOPAM is quickly and completely absorbed after oral administration.It is extensively metabolized,its principal metabolite being 7-aminoclonazepam and minor metabolites being acetamide and hydroxylated derivatives.
It is excreted in urine almost entirely as its metabolites in free or conjugated form.
CLOPAM crosses the placental barrier.
CLOPAM is used alone or as adjunct in the treatment of petit-mal epilepsy, akinetic and myoclonic seizures.
Dosage and Administration
The daily dose should be divided into three equal doses if possible.If doses are not equally divided, the largest dose should be given in the evening.
Usual Adult Dose:
0.5 mg three times a day, and the dose can be increased if necessary in increments of 0.5 - 1 mg every three days until seizures are controlled or until side effects prevent any further increase.
The maintenance dose must be individualized depending on the patient's response.
The maximum adult therapeutic dose is 20 mg/day.
CLOPAM should be given with care in patients with impaired renal or hepatic function.
It is advised not to use CLOPAM during pregnancy and lactation.
CLOPAM must not be withdrawn abruptly and the dosage should be gradually decreased.
CLOPAM may reduce the patient's ability to drive vehicles or operate machinery.
Concomitant administration of hepatic enzyme inducers, such as phenobarbitone or phenytoin may enhance the metabolism of CLOPAM.
Concomitant intake of alcohol may affect the patient's response to CLOPAM.
CLOPAM may enhance the effects of C.N.S. depressants.
Pre-existing C.N.S. depression or coma.
CLOPAM may cause fatigue, drowsiness and respiratory depression.
Prolonged use of CLOPAM may lead to development of dependence.
Box of 3 blisters of 10 scored tablets each.