Each tablet contains:
Doxazosin (as monohydrate) 1, 2, or 4 mg
Properties and Mode of Action reduces both pre-load and after-load and produces an improvement in cardiac output in patients with heart failure.
DOSIN is a selective a 1- adrenergic receptor blocker that produces peripheral dilatation of both arterioles and veins thus reducing peripheral resistance and so is used in the management of hypertension.
DOSIN may relieve the symptoms of urinary obstruction in patients with benign prostatic hyperplasia by reducing smooth muscle tone in the prostate and bladder neck.
DOSIN is well-absorbed after oral administration to give peak blood concentrations 2 hours after a dose.It is extensively metabolized in the liver and is excreted in faeces as metabolites and a small amount of unchanged drug.
Management of hypertension, with or without other antihypertensives.
Relief of symptoms of urinary obstruction in benign prostatic hyperplasia.
Dosage and Administration
1 mg preferably at bedtime and it may be increased after 1 or 2 weeks according to the patient's response.
Up to 4 mg once daily.Doses of 16 mg should not be exceeded.
Benign Prostatic Hyperplasia:
2 - 4 mg daily.Doses of 8 mg should not be exceeded.
Treatment with DOSIN should be cautiously introduced because of the risk of sudden collapse following the initial dose.
DOSIN should be used with caution in patients with:
Renal or hepatic impairment and in the elderly.
DOSIN may cause drowsiness or dizziness, so patients should not drive or operate machinery in such case.
Known hypersensitivity to quinazolines.
Heart failure caused by mechanical obstruction such as: aortic or mitral valve stenosis,pulmonary embolism or restrictive pericardial disease.
Pregnancy and lactation.
DOSIN may cause postural hypertension following the initial dose which can be avoided by starting treatment with a low dose preferably at night.
Less frequently, nausea, headache or palpitation may occur.
Rarely, oedema, diarrhoea, vomiting, vertigo or skin rash may occur.
Box of 2 blisters of 10 tablets each.